CCN3: a key growth regulator in Chronic Myeloid Leukaemia
نویسندگان
چکیده
منابع مشابه
The matricellular protein CCN3 regulates NOTCH1 signalling in chronic myeloid leukaemia
Deregulated NOTCH1 has been reported in lymphoid leukaemia, although its role in chronic myeloid leukaemia (CML) is not well established. We previously reported BCR-ABL down-regulation of a novel haematopoietic regulator, CCN3, in CML; CCN3 is a non-canonical NOTCH1 ligand. This study characterizes the NOTCH1–CCN3 signalling axis in CML. In K562 cells, BCR-ABL silencing reduced full-length NOTC...
متن کاملChronic Myeloid Leukaemia
Chronic myeloid leukaemia (CML) is a malignant myeloproliferative disorder of haemopoietic stem cells, giving rise to abnormally elevated numbers of myeloid cells in peripheral blood and myeloid hyperplasia in bone marrow. Uncontrolled production of myeloid precursors results in increased levels of maturing granulocytes, mainly neutrophils but also eosinophils and basophils. Elevated numbers of...
متن کاملExpression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow
Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute m...
متن کاملleukaemia, myelodysplastic syndromes, and chronic myeloid leukaemia
Introduction The standard approach to the diagnosis of acute leukaemia and myelodysplasia has been based on the morphology and percentage of malignant haemopoietic cells in peripheral blood and in an aspirated sample of bone marrow. The FAB group reports on acute leukaemia have emphasised the value of additional information gained from cytochemistry,' and immunological studies and cytogenetics ...
متن کاملsyndromes, and chronic myeloid leukaemia
Introduction The standard approach to the diagnosis of acute leukaemia and myelodysplasia has been based on the morphology and percentage of malignant haemopoietic cells in peripheral blood and in an aspirated sample of bone marrow. The FAB group reports on acute leukaemia have emphasised the value of additional information gained from cytochemistry,' and immunological studies and cytogenetics ...
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ژورنال
عنوان ژورنال: Journal of Cell Communication and Signaling
سال: 2009
ISSN: 1873-9601,1873-961X
DOI: 10.1007/s12079-009-0058-2